{
  "_id": "6a1f2325b401979e73420a21",
  "Package": "ActiveDriver",
  "Version": "1.0.0",
  "License": "GPL (>= 2)",
  "Description": "A mutation analysis tool that discovers cancer driver\ngenes with frequent mutations in protein signalling sites such\nas post-translational modifications (phosphorylation,\nubiquitination, etc). The Poisson generalised linear regression\nmodel identifies genes where cancer mutations in signalling\nsites are more frequent than expected from the sequence of the\nentire gene. Integration of mutations with signalling\ninformation helps find new driver genes and propose candidate\nmechanisms to known drivers. Reference: Systematic analysis of\nsomatic mutations in phosphorylation signaling predicts novel\ncancer drivers. Juri Reimand and Gary D Bader. Molecular\nSystems Biology (2013) 9:637 <doi:10.1038/msb.2012.68>.",
  "Title": "Finding Cancer Driver Proteins with Enriched Mutations in\nPost-Translational Modification Sites",
  "Authors@R": "person(\"Juri\", \"Reimand\", email = \"juri.reimand@utoronto.ca\", role = c(\"aut\", \"cre\"))",
  "Collate": "'ActiveDriver.R'",
  "RoxygenNote": "6.0.1.9000",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-16 07:01:09 UTC",
    "User": "root"
  },
  "Author": "Juri Reimand [aut, cre]",
  "Maintainer": "Juri Reimand <juri.reimand@utoronto.ca>",
  "Repository": "https://reimand0.r-universe.dev",
  "Date/Publication": "2017-08-23 19:55:51 UTC",
  "RemoteUrl": "https://github.com/cran/ActiveDriver",
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  "_created": "2026-05-16T07:01:09.000Z",
  "_published": "2026-06-02T18:38:29.723Z",
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  "_status": "success",
  "_host": "GitHub-Actions",
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  "_commit": {
    "id": "5b8288599ff085119d1841fd1de84f65e9903236",
    "author": "Juri Reimand <juri.reimand@utoronto.ca>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 1.0.0\n",
    "time": 1503518151
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    "name": "Juri Reimand",
    "email": "juri.reimand@utoronto.ca",
    "login": "reimand0",
    "uuid": 19268349
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  "_registered": true,
  "_dependencies": [
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      "role": "Depends"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    },
    {
      "package": "MASS",
      "role": "Imports"
    }
  ],
  "_owner": "cran",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_contributors": [
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    }
  ],
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    "type": "user",
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  "_downloads": {
    "count": 235,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ActiveDriver"
  },
  "_mentions": 29,
  "_searchresults": 6,
  "_rbuild": "4.6.0",
  "_assets": [
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    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "manual.pdf"
  ],
  "_realowner": "reimand0",
  "_cranurl": false,
  "_releases": [
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      "version": "1.0.0",
      "date": "2017-08-23"
    }
  ],
  "_exports": [
    "ActiveDriver",
    "read_fasta"
  ],
  "_datasets": [
    {
      "name": "kinase_domains",
      "title": "Example kinase domains for ActiveDriver",
      "object": "ActiveDriver_data",
      "file": "ActiveDriver_data.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "gene",
        "position",
        "phos",
        "residue"
      ],
      "rows": 1,
      "table": true,
      "tojson": true
    },
    {
      "name": "mutations",
      "title": "Example mutations for ActiveDriver",
      "object": "ActiveDriver_data",
      "file": "ActiveDriver_data.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "gene",
        "sample_id",
        "position",
        "wt_residue",
        "mut_residue"
      ],
      "rows": 408,
      "table": true,
      "tojson": true
    },
    {
      "name": "phosphosites",
      "title": "Example phosphosites for ActiveDriver",
      "object": "ActiveDriver_data",
      "file": "ActiveDriver_data.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "gene",
        "position",
        "residue",
        "kinase"
      ],
      "rows": 131,
      "table": true,
      "tojson": true
    },
    {
      "name": "sequence_disorder",
      "title": "Example protein disorder for ActiveDriver",
      "object": "ActiveDriver_data",
      "file": "ActiveDriver_data.RData",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "sequences",
      "title": "Example protein sequences for ActiveDriver",
      "object": "ActiveDriver_data",
      "file": "ActiveDriver_data.RData",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "ActiveDriver",
      "title": "Identification of active protein sites (post-translational modification sites, signalling domains, etc) with specific and significant mutations.",
      "topics": [
        "ActiveDriver"
      ]
    },
    {
      "page": "kinase_domains",
      "title": "Example kinase domains for ActiveDriver",
      "topics": [
        "kinase_domains"
      ]
    },
    {
      "page": "mutations",
      "title": "Example mutations for ActiveDriver",
      "topics": [
        "mutations"
      ]
    },
    {
      "page": "phosphosites",
      "title": "Example phosphosites for ActiveDriver",
      "topics": [
        "phosphosites"
      ]
    },
    {
      "page": "read_fasta",
      "title": "Read FASTA file as character vector.",
      "topics": [
        "read_fasta"
      ]
    },
    {
      "page": "sequence_disorder",
      "title": "Example protein disorder for ActiveDriver",
      "topics": [
        "sequence_disorder"
      ]
    },
    {
      "page": "sequences",
      "title": "Example protein sequences for ActiveDriver",
      "topics": [
        "sequences"
      ]
    }
  ],
  "_rundeps": [
    "MASS"
  ],
  "_score": 2,
  "_indexed": true,
  "_nocasepkg": "activedriver",
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